Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

Blood Spotlight XMEN disease: a new primary immunodeficiency affecting Mg regulation of immunity against Epstein-Barr virus

Epstein-Barr virus (EBV), a B-cell–tropic gammaherpesvirus present in latent form, is widespread and affects the majority of adults and childrenworldwide.Whilemost infections are asymptomatic or cause nonspecific symptoms, about 75% of adolescents and young adults with primary EBV infection develop mononucleosis. Moreover, hosts with acquired immunodeficiencies secondary to posttransplantation ...

Schizophrenia: a multisystem disease?

A multisystem disease is one that usually affects a number of organs and tissues during the course of the illness (Dorland, 2008). It has long been observed that some individuals with schizophrenia have levels of general physical illnesses in excess of that seen in the general population, but recent studies suggest that most people with schizophrenia have comorbid physical disease and multiple ...

Bone and joint manifestations of primary immunodeficiency patients: review article

Primary Immune Deficiencies are a group of heterogeneous disorders that involve the innate or acquired immune system, or a combination of them. The underlying disorder may be related to decreased levels or function, or a complete lack of one or more components of the immune system in general. These diseases can occur with a prevalence of about 1 in 10000 live births. According to the fourth upd...

Dystrophia myotonica: a multisystem disease.

AN AI~A~S'rHESIOLOCIST is aware of the need for caution when confronted with a patient suffering from a myotonic syndrome. On reviewing the literature, 1,2 it becomes evident that the stress has been on the myotonic aspects of the disease. However, dystrophia myotonica is a multisystem disease, and the following case report and related discussion illustrate the many facets which need considerat...

Combined immunodeficiency and thymic abnormalities.